Hello,
I see two situation where it is useful.
If you use a very accurate mount (10 micron, Ioptron with encoder, EQ8 RH ...) you don't need to use autoguiding but if you want to increase the SNR you must regularly shift the image on the sensor so you need dithering.
If you use a more comon mount (azeq6 ...) without autoguiding the periodic error causes the image to move on the sensor but this movement is slow and not random so it's not good and it is better to use dithering.
Lionel