Did a quick test last night at gain -20 on my 2600 and it worked great with my fast f2.8 optics.
There was a half moon and I managed to get 90x120s subs without any filters at all on M78.
The increased read noise was tamed very well and the stars were not overly saturated at f2.8.
Overall I am happy with the results from just 3 hours of subs.
Stacked, gradient extraction and star removal in Siril and then just tweaked in LR. No fancy processing or colour corrections.