Always remember, more information is better, even over multiple nights on the same target. Start researching post-processing as you can turn out far better results than the scope can by stacking and stretching manually.
If you don't want to mess with post-processing, keep your targets to the E & W, and at lower altitudes to reduce field rotation. Stick with 10-second subs, just more of them.
Lots of good information in the Smart Telescope section of the Cloudy Nights forums.
