Eventhorizon "I’ve enabled enhance after goto and it does nothing to correct the problem. " Has not been my experience. I've always had this turned on, and when I set the rotation for Andromeda it started capturing subframes at the correct angle.
But what I found was that it was so slow with any rotation angle other than 0 or 90 degrees (even if only zoomed 1.6x or so to just cover andromeda) that I found it was better to just select 2x zoom with either 0 or 90 degrees to cover the whole thing and more, and go. Like so.

It has to do with the way the sub frames are setup to overlap especially around the edges. It's faster to overlap a bunch of straight sides, than a whole bunch of corners.