For Deep Space Astrophotography….., 
Others will probably disagree but I listen to the developers of various software for my technical reasoning plus observing my results over years
 
In regard to the benefits of good calibration, there’s simply no substitute for a clean dust spot free , corrected evenly illuminated flat field with no vignetting to give your images the best starting point upon commencement of post processing. 
You owe it to both your camera and yourself.
 
I image from both Bortle 8 heavy light polluted skies ( backyard in a big City ) and from my NexDome located under Bortle 3 dark skies 
I’ve used both ZWO2600MC and  ZWO2600MM cameras for the past 7 years
 
Telescopes 6” , 8” and 10” carbon Newts
 
My calibration recommendation …..,
Darks to calibrate your Lights 
Flat Darks to calibrate your Flats
 
All frames same Temperature, same Gain , same camera orientation 
Darks to match Lights exposure 
Flat Darks to match Flats exposure
 
I create a Dark library to cover most of my Light frame exposures and Gain settings for Broadband and Narrowband. My library is good for 12 to 15 months before creating a new one.
 
Why use Flat Darks in lieu of Bias ?
Flat Darks are the Gold Standard for Calibration of Flats regardless of CMOS camera type and brand 
They don’t take too much time or effort after your session or on another night provided you don’t move the image train / camera.
 
The Sony IMX571 sensor still exhibits RTN ( random telegraph noise ) in the form of hot pixels so Darks will totally eliminate this issue ( even if you cool your camera to -10C to -15C )
 
There are no short cuts in Calibration, spend the time and effort and your images will benefit.
 
PS: I forgot to mention about Dithering !!
Dithering is just as important as Calibration when it comes to improving your images 
Dithering eliminates fixed pattern noise like walking noise , vertical and horizontal column noise and similar types of noise
 
Clear Skies
Martin