Did you get this resolved yet?? I have the exact same issue from what I can see.
Installing driver on a new mini PC. I have the older one still that has the ASICAMUSB3.sys driver file present on the system and it's been working fine.
Meanwhile on the new PC, the install completes but I get the "blocked by windows" pop-up as soon as the camera connects and the device remains yellow banged in device manager and unusable.
This seems like a BIG problem! If there's no version of the installer/driver that will work with the present version of Windows. My camera is difference than yours (ASI120MM). The driver package is the same though. By inference, it seems like ALL ASI cameras would run into this same issue with current Windows if there's no software that passes whatever gate Windows is applying here. Would love to be wrong about that of course 😉