I purchased ASI1600MM pro in mid November last year, and unfortunately my camera has exactly the same noise issue.
EA8519B3-A564-43D9-AD37-B3668A535E68.jpeg
As I’m still a beginner and it’s my first cold CMOS camera, I thought that was caused by my bad calibration or light pollution but the noise is found to be a hardware defect.
I emailed zwo support and Sean and Sam replied quickly and I already returned the camera for repair.
Though, I have been struggling hard to reduce noise with pixinsight cosmetics correction and mask post processing. For bright objects I could still get decent images.
https://instagram.com/p/Bd40ikbBXV4/
But I can’t wait to see the results with the repaired camera. :)