Yes, star alignment with hand controller then connect. I have the V5 Synscan hand controller which has a USB MALE connector on bottom right of the hand controller. I connect directly to it that way from ASIair, meaning 1 USB cable from ASIair to Synscan hand controller.
Other hand controllers vary eg: USB to RS-232, Micro USB connection etc......
Luckily my Skywatcher EQ6-R came with a hand controller with a direct USB connection that I can use leaving the RJ12 PORT open for the GPS external module.
Hope this helps.