Hello, when you say you run a dedicated power supply, do you mean to this camera alone or to your astronomy setup? To minimize these issues on this camera, you should power it with at least a 36W power supply (12V, 3A) for this camera alone. I have mine plugged into a 60W PS (12V, 5A) and have not had any issues on any laptop/desktop I've used. It sounds like you have a custom power supply, but you might double check the power output in watts compared to what may be required for any equipment attached.