astrosatch until latest version I didn't have that kind of problems
The board layout has lots to do with it; thus the Intel White Paper.
When one of Apple's Mac mini upgraded to USB 3 some years ago, it too has a problem: one of the USB connectors cannot be used because it causes the bluetooth mouse to becomes laggy. But moving the USB device just one USB slot over, everything was fine. Take a look at this article:
https://www.techbout.com/fix-laggy-slow-mouse-on-mac-28718/
The third version of the ASIAIR is not a stock Raspberry Pi 4 board, but uses a Raspberry Pi Compute Module 4 daughter card (same ARM chip as in the Raspberry Pi 4B) and a Raspberry Pi CM4 WiFi module, with ZWO's own motherboard. If you look closely, the locations of the USB connectors have moved.
We don't know for sure if USB 3 is the problem, but it is starting to smell like it, especially with people still using the flat cables that come with the ZWO equipment.
I suspect (from the fatness) of the red connectors that I use that the data lines may not be individually shielded, but the entire cable is shielded. And in any case, as I mentioned earlier, except for the eero mesh backhaul signal, I do not use WiFi.
Anyone with a problem should try the really fat shielded USB cables. And, if it is related to board layout, try using a different USB port on the ASIAIR (like the Mac Mini case above).
But I also used a USB hub, so that I just need to deal with one super critical cable location (the one that plugs into the ASIAIR), plus one other USB port for an SSD. This is the ASIAIR end of my arrangement:
Notice a short blue USB cable that runs from the ASIAIR to the hub. The big white square under the hub is the eero mesh router, and the red Samsung rectangle is an SSD. The eero gets quite warm and provides the heat to warm both the hub and the SSD when it is cold.
Chen