Rodolphe.. Well UHUBCTL ran but didn't change the issue BUT on that thought, I unplugged the EFW and plugged it immediately back in, and the EFW will now work after using INDI/EKOS.. Don't know if I lose the effects of calibration then? Seems like an endless loop!! No idea with none of the USB resets seem to make ANY difference.. You would think a power reset like UHUBCTL would be the same effect as unplugging and plugging back in. Here's the result from UHUBCTL (nice utility.. Installed with Synaptic and ran as SUDO)
pi@raspberrypi:~ $ sudo uhubctl
Current status for hub 2 [1d6b:0003 Linux 5.15.76-v8+ xhci-hcd xHCI Host Controller 0000:01:00.0, USB 3.00, 4 ports, ppps]
Port 1: 02a0 power 5gbps Rx.Detect
Port 2: 0203 power 5gbps U0 enable connect [03c3:1604 ZWO ASI1600MM Pro]
Port 3: 02a0 power 5gbps Rx.Detect
Port 4: 02a0 power 5gbps Rx.Detect
Current status for hub 1-1.4 [05ac:1006 Apple, Inc. Keyboard Hub 000000000000, USB 2.00, 3 ports, ppps]
Port 1: 0100 power
Port 2: 0303 power lowspeed enable connect [05ac:0220 Apple, Inc Apple Keyboard]
Port 3: 0303 power lowspeed enable connect [045e:0039 Microsoft Microsoft 5-Button Mouse with IntelliEye(TM)]
Current status for hub 1-1.2 [04b4:6572 USB2.0 Hub, USB 2.00, 4 ports, ppps]
Port 1: 0100 power
Port 2: 0103 power enable connect [03c3:1f01 ZW0 ZWO EFW]
Port 3: 0503 power highspeed enable connect [03c3:224a ZWO ASI224MC]
Port 4: 0100 power
Current status for hub 1-1 [2109:3431 USB2.0 Hub, USB 2.10, 4 ports, ppps]
Port 1: 0100 power
Port 2: 0503 power highspeed enable connect [04b4:6572 USB2.0 Hub, USB 2.00, 4 ports, ppps]
Port 3: 0100 power
Port 4: 0503 power highspeed enable connect [05ac:1006 Apple, Inc. Keyboard Hub 000000000000, USB 2.00, 3 ports, ppps]
Current status for hub 1 [1d6b:0002 Linux 5.15.76-v8+ xhci-hcd xHCI Host Controller 0000:01:00.0, USB 2.00, 1 ports, ppps]
Port 1: 0503 power highspeed enable connect [2109:3431 USB2.0 Hub, USB 2.10, 4 ports, ppps]