I have an RC6 on the AM5 at native 1370mm fl. Guiding is PHD2, not ASIAir.
When it was being used on a CEM, OAG setup of Askar OAG (10mm prism) plus 174mm mini worked very well with guide exposures of 1.5-2 sec.
On the AM5, I have tried 0.5 to 1.5 sec guide exposures and settled at 0.8 sec. Location is in a metro, so high LP (skies around 17 mpsas).
The OAG works fine in star rich areas at 0.8 sec. I get 8-9 stars in multistars. Where star fields are poor (Virgo, etc), or near the light dome, I get only 1-2 stars, maybe 3. You might get more if you have low LP.
I then tried a 60mm F4 guidescope with an old ASI385 I had lying around. With this, there are always 9 guidestars and I feel the guiding in star poor areas is better - lower by about 0.1"-0.2" rms total. Not significant when imaging at 1.6"/px, but desirable at 0.55"/px.
In most areas, the difference in guiding doesn't show up in the images. But in the star-poor areas, it does. So I just use the guidescope now.
I could probably go down to 0.5sec as well. I fiddled around with the minmove - had to reduce it compared to OAG.
The guidescope is in rings which are bolted to the top vixen dovetail. The guide camera and imaging camera are well aligned - both put the same star in the centre.
The 220mm actually has larger pixels than the 385. That would push the guiding pixel scale away from the imaging scale. I am planning to try a smaller pixel camera (a 290mm I have) and see if that improves it further as the guiding pixel scale will come closer to the imaging scale.